Would Benzoyl Peroxide oxidize Chlorhexidine Gluconate in a gel?

It seems like the amine groups in Chlorhexidine could be oxidized, but maybe it could be avoided with the right formulation. The intended application would be for pets.


  • Bill_TogeBill_Toge Member, Professional Chemist
    edited September 2016
    probably not; all the nitrogens are part of a conjugated biguanidine system (so they wouldn't react like amines), and one is conjugated with the benzene ring, making it even less reactive

    as ever, the best way to find out would be to try it and see!
    UK based formulation chemist. Strongest subjects: hair styling, hair bleaches, hair dyes (oxidative and non-oxidative) I know some stuff about: EU regulations, emulsions (O/W and W/O), toothpaste, mouthwash, shampoos, other toiletries
  • Thanks Bill! I guess you could make two samples with and wo Chlorhexidine, incubate them at 40C for a week and have the Benzoyl Peroxide % assayed by HPLC ($125/sample)?

  • johnbjohnb Member, Professional Chemist
    Where would you be selling this product?

    Take great care that you comply with licensing requirements for your marketplace.

    Do you know if the combination you are suggesting is effective? There are gazillions of products already on the market so your effort would have to be something pretty special - which, with all due respect, I don't think it is.

  • ZinkZink Member
    edited October 2016
    Yes, nothing special here, move along..
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