Capixyl... what is it and is it a good ingredient to add to a shampoo formula?

I have been doing some research on capixyl and I want to get some insight on what exactly it does and is it an ingredient i should add to my shampoo formula? Any information would be great


  • If you're going to add it to your shampoo, only put it in for marketing (0.001%). Shampoo is meant to rinse-off, putting actives in there will just go to waste. 

    Personally I doubt the ingredient does much. The  supplier's study doesn't look that great and they were the ones with the most motivation to make it look good!
  • PerryPerry Administrator, Professional Chemist
    edited April 2020
    The supplier claims it does this...

    "Capixyl™ is an innovative and unique active complex designed to prevent and stop the hair loss process, stimulate hair growth and reduces inflammation in the scalp. Capixyl™ is a biomimetic signal peptide (acetyl tetrapeptide-3) combined with a red clover extract rich in Biochanin A, working synergistically on DHT modulation via the inhibition of 5-α reductase and on the stimulation of ECM renewal and anchoring proteins."

    But I agree with @EVchem - this is a claims ingredient and you shouldn't expect that it will work to stop hair loss, especially delivered from a shampoo.

    Incidentally, if it did work to stop hair loss and stimulate hair growth, it would be an illegal drug.
  • PharmaPharma Member, Pharmacist
    If you want a peptide to show any skin penetration, you have to apply it with a special formulation or a fancy injector device. Example reading HERE.
    Biochanin A is an isoflavone with weak oestrogenic activity (used in menopause instead of hormone substitution) and possible cancer preventive action (did test related compounds during my postdoc). Apart from a hypothetical 'feminising' effect, I don't know of any reason why red clover or its constituents should help against hair loss.
  • Would it make more sense to put it in a leave in hair spray or is there really no benefit to this compound. What would be the best way to deliver it in a product?
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