Adapalene

Has anyone worked with adapalene? Where did you buy it from? Sigma has it, but it's $71 for 10 mg.  Looking at the prices of adapalene containing products, i can't justify paying the Sigma price....

Any pointers on formulating with it would be great also!  Since it's so expensive, I'd like to avoid batch failures.

Many thanks!


Comments

  • BelassiBelassi Member, PCF student
    I suspect the only real choices for buying it will be the original manufacturer or a China source. Not to mention that it is a drug not a cosmetic, surely?
    Cosmetic Brand Creation. Concept to name to IMPI search to logo and brand registration. In-house graphic design inc. Pantone specs. Cosmetic label and box design & graphics.
  • PharmaPharma Member, Pharmacist
    Belassi said:
    the original manufacturer or a China source.
    At least in Europe, adapalene is a drug and like most API (active pharmaceutical ingredient), the original manufacturer IS in China, just the 'cream maker' may be local and certainly won't sell APIs (they may donate small quantities to research & universities). The reason for the high Sigma price is that it's a small quantity at a very high purity, not that mush cosmetic grade. If you're looking for APIs, they are relatively cheap, require re-testing and sometimes re-purification, and a liaison in China or a visit to an API congress. They basically sell to everyone even if patent rights prohibit you from actually using what you buy.
  • @Pharma & @Belassi, thank you for your replies.
    i plan to simply purchase from Sigma, mostly to avoid having to re-purify.  Sometimes time &peace of mind is more valuable than money. 
  • PharmaPharma Member, Pharmacist
    Why don't you just buy Differin gel/cream for 1/10 of what you're going to pay for an equal amount of adapalene (BTW Sigma does only ship to companies, not private persons and has a minimal order fee which isn't that obvious when reading the terms & conditions).
  • Pharma said:
    Why don't you just buy Differin gel/cream for 1/10 of what you're going to pay for an equal amount of adapalene (BTW Sigma does only ship to companies, not private persons and has a minimal order fee which isn't that obvious when reading the terms & conditions).
    My friend wants an adapalene & SPF formulation.  It’s rather annoying to apply two separate products. I’m all set with Sigma 👍🏻
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